Lopez, J. M. & Maruenda, H Journal of Magnetic Resonance, 335, 107111. https://doi.org/10.1016/j.jmr.2021.107111

 The novel intra HNCA IP/AP E.COSY pulse sequence implemented allowed to measure ³J H^NH^a coupling constants by a simple and rapid two-dimensional ¹H-¹⁵N correlation experiment where the ¹⁵N frequency is encoded at the same time as the ¹J H^aC^a coupling evolution. The advantage with respect to the conventional 3D HNCA E.COSY pulse sequence is the dimensionality reduction to a simple 2D experiment, which decreases acquisition time and facilitates data analysis. The performance of this new experiment was demonstrated with an ubiquitin sample at 500 MHz.