The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.
Twenty-three heterocyclic compounds were evaluated for their potential as trypanothione reductase inhibitors. As a result, the harmaline, 10-thiaisoalloxazine, and aspidospermine frameworks were identified as the basis of inhibitors of Trypanosoma cruzi trypanothione reductase. None of the compounds inhibited glutathione reductase. Their toxicity toward promastigotes of Leishmania amazonensis was assessed.
Autor(es):Galarreta BC, Sifuentes R, Carrillo AK, Sanchez L, Amado Mdel R, Maruenda H
Año: 2008
Título de la revista: Bioorg Med Chem.
Volumen: 16
Página inicial - Página final: 6689–6695
Url: https://www.sciencedirect.com/science/article/pii/S0968089608005154?via%3Dihub#aep-figure-id15